Family of small (30-35 residue) cysteine-rich cationic proteins found in vertebrate phagocytes (notably the azurophil granules of neutrophils) and active against bacteria, fungi and enveloped viruses. May constitute up to 5% of the total protein. Insect defensins have some sequence homology with the vertebrate forms.

Dictionary of molecular biology. 2004.

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  • defensins — A class of basic antibiotic polypeptides, found in neutrophils, that kill bacteria by causing membrane damage. These cytotoxic peptides contain 29–38 amino acid residues. [L. de fendo, pp. de fensum, to repel, avert, + in] …   Medical dictionary

  • insect defensins — See defensins …   Dictionary of molecular biology

  • Defensin — Monomeric and dimeric structures of human beta defensin HBD 2 Defensins are small cysteine rich cationic proteins found in both vertebrates and invertebrates. They have also been reported in plants.[1] …   Wikipedia

  • Alpha defensin — Mammalian defensin Structure of defensin HNP 3.[1] Identifiers Symbol Defensin 1 …   Wikipedia

  • Дефензины — Мономер(a) и димер(b) человеческого дефензина HBD2.[1] Дефензины (англ. defensin, от англ. defense защита) катионные пептиды иммунной системы, активные в отношении бактерий, грибков и многих оболочечных и без оболочечных вирусов. Состоят из 18 45 …   Википедия

  • Дефензин — Мономер(a) и димер(b) человеческого дефензина HBD2 …   Википедия

  • Beta defensin — Pfam box Symbol = Defensin beta Name = Beta defensin width =200 caption = Pfam= PF00711 InterPro= IPR001855 SMART= Prosite = SCOP = 1bnb TCDB = OPM family= 56 OPM protein= 1ut3 PDB=PDB3|1ijuC:33 68 PDB3|1kj5A:33 68 PDB3|1ijvB:33 68PDB3|1e4sA:33… …   Wikipedia

  • Paneth cell — Paneth cells provide host defense against microbes in the small intestine. They are functionally similar to neutrophils. When exposed to bacteria or bacterial antigens, Paneth cells secrete a number of antimicrobial molecules into the lumen of… …   Wikipedia

  • DEFB103A — Defensin, beta 103B PDB rendering based on 1kj6 …   Wikipedia

  • Cryptdin — is a term that refers to mammalian defensins of the alpha subfamily that are produced within the mouse small bowel. The word is a portmanteau that combines the terms crypt and defensin . Formally, in the scientific literature they are known as… …   Wikipedia

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